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Biomarkers. 2018 Feb;23(1):25-32. doi: 10.1080/1354750X.2017.1306754. Epub 2017 Apr 3.

The value of microparticles in detecting acute rejection episodes after liver transplantation.

Author information

1
a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
2
b Department of Medicine I Cardiology, Angiology and Intensive Care , General Hospital Chemnitz gGmbH , Chemnitz , Germany.
3
c Department of Visceral , Transplant, Thoracic, and Vascular Surgery, University Hospital Leipzig , Leipzig , Germany.
4
d Department of General , Visceral, and Vascular Surgery, University Hospital Jena , Jena , Germany.
5
e Department of Traumatology, Hand and Orthopedic Surgery , Harzklinikum Dorothea Christiane Erxleben GmbH , Quedlinburg , Germany.

Abstract

CONTEXT:

Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.

OBJECTIVE:

We analyzed the correlation of plasma microparticle levels (MP) with AR.

MATERIALS AND METHODS:

MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.

RESULTS:

CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.

DISCUSSION AND CONCLUSION:

MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.

KEYWORDS:

T cell-derived microparticles; endothelial cell-derived microparticles; graft monitoring; non-invasive marker; regulatory T cells

PMID:
28303731
DOI:
10.1080/1354750X.2017.1306754
[Indexed for MEDLINE]

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