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Int J Sports Med. 2017 May;38(5):402-406. doi: 10.1055/s-0042-118649. Epub 2017 Mar 16.

Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts.

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Department of Training Science, Nippon Sport Science University, Tokyo, Japan.
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Health Promotion and Exercise Program, National Institute of Health and Nutrition, NIBIOHN, Tokyo, Japan.
Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.


α-Actinin-3 (ACTN3) R577X polymorphism is associated with muscular strength and power. This study was performed to investigate the association between ACTN3 R577X polymorphisms and flexibility as another component of fitness in 2 cohorts. Cohort 1 consisted of 208 men and 568 women (ages 23-88), while Cohort 2 consisted of 529 men and 728 women (ages 23-87). All participants were recruited from the Tokyo metropolitan area and underwent a battery of tests to assess their grip strength and sit-and-reach flexibility. Genotyping results were analyzed for ACTN3 (rs1815739) polymorphism using the TaqMan approach. In Cohort 1, sit-and-reach in the RR genotype (35.3±0.7 cm) was significantly lower than those in the RX and XX genotypes (37.2±0.3 cm) even after adjusting for sex, age, and exercise habit as covariates (P<0.01). In Cohort 2, sit-and-reach tended to be lower in RR (38.1±0.6 cm) than in RX and XX (39.1±0.3 cm), but the differences were not significant (P=0.114). Analysis in pooled subjects indicated that RR was associated with significantly lower flexibility than RX and XX (P=0.009). The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.

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