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Arch Dermatol Res. 2017 Jul;309(5):397-402. doi: 10.1007/s00403-017-1731-6. Epub 2017 Mar 16.

Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation.

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Biotechnology Research Institute, R&D Division, Celltrion, Inc., Incheon, Republic of Korea.
Celltrion Chemical Research Institute, Yongin, Republic of Korea.
Department of Dermatology, Seoul Paik Hospital, Inje University College of Medicine, Mareunnae-ro 9, Jung-gu, Seoul, Republic of Korea.


Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1-4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVK-L-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.


L-ascorbic acid; Palmitoyl-KVK; Skin pigmentation; Skin wrinkles

[Indexed for MEDLINE]

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