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Bioorg Med Chem. 2017 Apr 15;25(8):2518-2523. doi: 10.1016/j.bmc.2017.03.013. Epub 2017 Mar 6.

Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.

Author information

1
Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
2
Università degli Studi di Firenze, Department of Chemistry "Ugo Schiff", Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy.
3
University of Naples "Federico II", Department of Chemical Sciences, Via Cintia 4, I-80126 Naples, Italy.
4
Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.

Abstract

A series of selenides, diselenides and organoselenoheterocycles were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV, VII and IX, involved in a variety of diseases among which glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors etc. These investigated compounds showed inhibitory action against these isoforms and some of them were selective for inhibiting the cytosolic over the membrane-bound isoforms, thus making them interesting leads for the development of isoform-selective inhibitors.

KEYWORDS:

Carbonic anhydrase; Diselenides; Inhibitors; Metalloenzymes; Selenides; Selenium; Selenoheterocycles

PMID:
28302505
DOI:
10.1016/j.bmc.2017.03.013
[Indexed for MEDLINE]

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