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BMC Nephrol. 2017 Mar 16;18(1):90. doi: 10.1186/s12882-017-0502-0.

Effects of stroke on changes in heart rate variability during hemodialysis.

Huang JC1,2,3,4, Chen CF5, Chang CC6,7,8, Chen SC1,2,3,4, Hsieh MC9,10, Hsieh YP11,12,13, Chen HC2,14.

Author information

1
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
2
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
3
Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
4
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
5
Division of Neurology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
6
Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nanxiao Street, Changhua City, 500, Taiwan.
7
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
8
Program for Aging, China Medical University, Taichung, Taiwan.
9
Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
10
Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
11
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 102407@cch.org.tw.
12
Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, 135 Nanxiao Street, Changhua City, 500, Taiwan. 102407@cch.org.tw.
13
School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 102407@cch.org.tw.
14
Faculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

BACKGROUND:

Stroke and low heart rate variability (HRV) are both associated with an unfavorable prognosis in hemodialysis patients. The relationship between stroke and changes in HRV during hemodialysis remains unclear.

METHODS:

This study measured differences between predialysis and postdialysis HRV (△HRV) in 182 maintenance hemodialysis patients, including 30 patients with stroke, to assess changes in HRV during hemodialysis, and also to compare results to 114 healthy controls.

RESULTS:

All predialysis HRV measurements had no differences between stroke patients and those without stroke, but were lower than healthy controls. Postdialysis very low frequency (VLF) (P < 0.001), low frequency (LF) (P = 0.001), total power (TP) (P < 0.001) and the LF/high frequency (HF) ratio (P < 0.001) increased significantly relative to predialysis values in patients without stroke, whereas postdialysis HRV did not increase in stroke patients. After multivariate adjustment, dialysis vintage was negatively associated with △VLF (β = -0.698, P = 0.046), △LF (β = -0.931, P = 0.009), and △TP (β = -0.887, P = 0.012) in patients without stroke. Serum intact parathyroid hormone (β = -0.707, P = 0.019) was negatively associated with △LF. Total cholesterol (β = -0.008, P = 0.001) and high sensitivity C-reactive protein (β = -0.474, P = 0.012) were inversely correlated with the △LF/HF ratio in patients without stroke.

CONCLUSION:

HRV in hemodialysis patients is lower than in the general population. Increase in △HRV was observed in hemodialysis patients without stroke but not in stroke patients. This result suggests suppressed autonomic nervous reactions against volume unloading during hemodialysis, which might contribute to unfavorable outcomes in hemodialysis patients but even more so in those with prior stroke. Nephrologists should notice the importance of △HRV especially in high-risk patients.

KEYWORDS:

Autonomic nervous system; Heart rate variability; Hemodialysis; Stroke

PMID:
28302058
PMCID:
PMC5353962
DOI:
10.1186/s12882-017-0502-0
[Indexed for MEDLINE]
Free PMC Article

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