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Mol Cells. 2017 Mar;40(3):163-168. doi: 10.14348/molcells.2017.0011. Epub 2017 Mar 17.

Signaling Pathways Controlling Microglia Chemotaxis.

Author information

1
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P.R. China.

Abstract

Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.

KEYWORDS:

P2Y12 receptor; activation; cell migration; chemotaxis; microglia

PMID:
28301917
PMCID:
PMC5386953
DOI:
10.14348/molcells.2017.0011
[Indexed for MEDLINE]
Free PMC Article

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