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PLoS One. 2017 Mar 16;12(3):e0171275. doi: 10.1371/journal.pone.0171275. eCollection 2017.

The association between frequent alcohol drinking and opioid consumption after abdominal surgery: A retrospective analysis.

Author information

1
Department of Anesthesiology, Mackay Memorial Hospital, Taipei City, Taiwan.
2
School of Medicine, National Yang-Ming University, Taipei City, Taiwan.
3
Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taoyuan City, Taiwan.
4
Department of Anesthesiology, National Yang-Ming University Hospital, Yilan City, Yilan County, Taiwan.

Abstract

AIMS:

It is perceived that patients with a history of frequent alcohol consumption require more opioids for postoperative pain control and experience less postoperative nausea and vomiting than patients without such a history. However, there is scarce evidence supporting this notion. The aim of this study was to assess association between frequent alcohol consumption and opioid requirement for postoperative pain control and occurrence of postoperative nausea and vomiting.

METHODS:

The medical records for 4143 patients using intravenous patient-control analgesia with opioids after abdominal surgery between January 2010 and September 2013 were obtained, and associations were sought between the cumulative opioid consumption (in intravenous morphine equivalence) per body weight (mg/kg) in the first 2 days after abdominal operation and several demographic and clinical variables by multiple regression analysis. The association between the occurrence of postoperative nausea and vomiting and several demographic and clinical variables was also sought by multiple logistic regression analysis.

RESULTS:

Frequent alcohol drinking, among other previously reported factors, was associated with increased opioid consumption for postoperative pain control (p < 0.001). The estimate effect of frequent alcohol drinking was 0.117 mg/kg. Frequent alcohol drinking was also associated with decreased risks of postoperative nausea (odds ratio = 0.59, p = 0.003) and vomiting (odds ratio = 0.49, p = 0.026).

CONCLUSIONS:

Frequent alcohol drinking was associated with increased opioid consumption for postoperative pain control and decreased risks of postoperative nausea and vomiting after abdominal surgery.

PMID:
28301483
PMCID:
PMC5354251
DOI:
10.1371/journal.pone.0171275
[Indexed for MEDLINE]
Free PMC Article

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