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Transcription. 2017 May 27;8(3):169-174. doi: 10.1080/21541264.2017.1291082. Epub 2017 Feb 8.

Genome-wide characterization of Mediator recruitment, function, and regulation.

Author information

1
a Basic Sciences Division , Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
2
b Department of Biology , Indiana University , Bloomington , IN USA.

Abstract

Mediator is a conserved and essential coactivator complex broadly required for RNA polymerase II (RNAPII) transcription. Recent genome-wide studies of Mediator binding in budding yeast have revealed new insights into the functions of this critical complex and raised new questions about its role in the regulation of gene expression.

KEYWORDS:

ChEC-seq; Mediator; Pre-initiation complex; RNA polymerase II; TFIID

PMID:
28301289
PMCID:
PMC5501378
DOI:
10.1080/21541264.2017.1291082
[Indexed for MEDLINE]
Free PMC Article

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