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Transcription. 2017 May 27;8(3):150-161. doi: 10.1080/21541264.2017.1289294. Epub 2017 Feb 8.

Transcription elongation.

Author information

1
a PHRI Center, NJMS, Rutgers, The State University of New Jersey , Newark , NJ , USA.
2
b Department of Molecular Biology and Genetics , Cornell University , Ithaca , NY , USA.
3
c Department of Microbiology & Immunology , Columbia University Medical Center , New York , NY , USA.

Abstract

This review is focused on recent progress in understanding how Escherichia coli RNAP polymerase translocates along the DNA template and the factors that affect this movement. We discuss the fundamental aspects of RNAP translocation, template signals that influence forward or backward movement, and host or phage factors that modulate translocation.

KEYWORDS:

Gre A/B; RNAP backtracking; bacteriophage transcription factors; transcription elongation; transcription-coupled repair

PMID:
28301288
PMCID:
PMC5501382
DOI:
10.1080/21541264.2017.1289294
[Indexed for MEDLINE]
Free PMC Article

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