Send to

Choose Destination
See comment in PubMed Commons below
Clin Chem. 1988 Feb;34(2):265-7.

The chemistry of aluminum and silicon in relation to Alzheimer's disease.

Author information

  • 1Imperial Chemical Industries Plc, Cheshire, U.K.


Aluminosilicates have been identified at the core of senile plaques in Alzheimer's disease, and aluminum has been found within neurons bearing neurofibrillary tangles. Here we show that aluminum species interact with silicic acid, Si(OH)4--a normal component of plasma--to form aluminosilicate species solubilized by citrate. A switch in the binding of aluminum from silicate to phosphate at pH less than 6.6 calls attention to the strong binding of cationic aluminum species to proximate phosphate groups, as in the inositol phosphates, and to the potential effect on the activity of the phosphoinositide-derived intracellular messenger system. The chemistry may throw light on the debated relationship between aluminum and Alzheimer's disease.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center