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J Biomed Opt. 2017 Mar 1;22(3):30501. doi: 10.1117/1.JBO.22.3.030501.

Compressed single pixel imaging in the spatial frequency domain.

Author information

1
Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California, United StatesbUniversity of California, Department of Biomedical Engineering, Irvine, California, United States.
2
Dankook University, Department of Biomedical Engineering, College of Medicine, Republic of Korea.
3
Colorado State University, School of Biomedical Engineering, Fort Collins, Colorado, United States.
4
Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California, United States.

Abstract

We have developed compressed sensing single pixel spatial frequency domain imaging (cs-SFDI) to characterize tissue optical properties over a wide field of view ( 35 ?? mm × 35 ?? mm ) using multiple near-infrared (NIR) wavelengths simultaneously. Our approach takes advantage of the relatively sparse spatial content required for mapping tissue optical properties at length scales comparable to the transport scattering length in tissue ( l tr ? 1 ?? mm ) and the high bandwidth available for spectral encoding using a single-element detector. cs-SFDI recovered absorption ( ? a ) and reduced scattering ( ? s ? ) coefficients of a tissue phantom at three NIR wavelengths (660, 850, and 940 nm) within 7.6% and 4.3% of absolute values determined using camera-based SFDI, respectively. These results suggest that cs-SFDI can be developed as a multi- and hyperspectral imaging modality for quantitative, dynamic imaging of tissue optical and physiological properties.

PMID:
28300272
PMCID:
PMC5352911
DOI:
10.1117/1.JBO.22.3.030501
[Indexed for MEDLINE]
Free PMC Article

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