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Acta Neurol Scand. 2017 Dec;136(6):727-731. doi: 10.1111/ane.12756. Epub 2017 Mar 15.

First clinical experience with levodopa/carbidopa microtablets in Parkinson's disease.

Author information

1
Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
2
Vällingby Läkarhus, Stockholm, Sweden.
3
Karolinska Institutet, Huddinge, Sweden.

Abstract

BACKGROUND:

Levodopa is the most effective symptomatic treatment throughout the course of Parkinson's disease, but as the disease progresses, there may be a need for individualized, fine-tuned treatments.

AIM:

To evaluate individualized levodopa/carbidopa dosing using microtablets dispensed with a dose dispenser, with respect to efficacy and usability as perceived by patients.

METHODS:

Patient records and dose dispenser reports from patients previously or currently treated with microtablets and a dose dispenser were reviewed, and a patient questionnaire concerning effect and usability was sent to patients.

RESULTS:

Eleven patient records, four dose dispenser reports and nine survey responses were obtained. The treatment effect was considered to be improved by six of nine patients. One-third found their bradykinesia to be improved, and the non-troublesome dyskinesia was unchanged according to a majority of patients; however, some experienced the duration and magnitude of troublesome dyskinesia to be worse. The usability was generally rated as good. The four dose dispenser reports obtained showed 97(±5)% total adherence.

CONCLUSIONS:

The experienced effect of treatment can, for some patients, be improved by the use of microtablets, and the dose dispenser was considered user-friendly. Further studies with a larger study population and prospective design are needed to confirm the results.

KEYWORDS:

Parkinson's disease; carbidopa; dose dispenser; levodopa; microtablets; pharmacotherapy

PMID:
28299787
DOI:
10.1111/ane.12756
[Indexed for MEDLINE]

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