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Geroscience. 2017 Feb;39(1):19-32. doi: 10.1007/s11357-017-9958-x. Epub 2017 Feb 13.

Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration.

Author information

1
Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
2
Byrd Alzheimer's Institute, Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
3
Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. pbickfor@health.usf.edu.
4
James A Haley VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL, USA. pbickfor@health.usf.edu.

Abstract

Astaxanthin (AXT) is a carotenoid with multiple health benefits. It is currently marketed as a health supplement and is well known for its antioxidant capacity. Recent evidence has emerged to suggest a broad range of biological activities. The interest in this compound has increased dramatically over the last few years and many studies are now applying this molecule across many disease models. Results from the current research are beginning to come together to suggest neuroprotective properties including anti-inflammatory, anti-apoptotic, and antioxidant effects, as well as the potential to promote or maintain neural plasticity. These emergent mechanisms of actions implicate AXT as a promising therapeutic agent for neurodegenerative disease. This review will examine and extrapolate from the recent literature to build support for the use of AXT in mitigating neuropathy in normal aging and neurodegenerative disease.

KEYWORDS:

Aging; Astaxanthin; Microglial function; Neural plasticity; Neuroprotection

PMID:
28299644
PMCID:
PMC5352583
DOI:
10.1007/s11357-017-9958-x
[Indexed for MEDLINE]
Free PMC Article

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