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J Indian Soc Periodontol. 2016 Jul-Aug;20(4):441-445. doi: 10.4103/0972-124X.181245.

Changes of the peri-implant soft tissue thickness after grafting with a collagen matrix.

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Department of Oral Hygiene, Claudiana University of Applied Health Sciences, Bolzano, Italy.
Division of Periodontology, School of Dentistry, Catholic University, Rome, Italy.
Department of Periodontology, School of Dentistry, Loma Linda University, Loma Linda, CA, USA.
Department of Oral Surgery, School of Dentistry, University of Duesseldorf, Duesseldorf, Germany.



The aim of this study was to determine the treatment outcome of the use of a porcine monolayer collagen matrix (mCM) to increase soft-tissue volume as a part of implant site development.


Implants were placed in single sites in 27 patients. In the test group, mCM was used for soft-tissue augmentation. No graft was placed in the control group. Soft-tissue thickness (STTh) was measured at the time of surgery (T0) and 6 months postoperatively (T1) at two sites (STTh 1, 1 mm below the gingival margin; STTh 2, 3 mm below the mucogingival margin).


Significant increases (P < 0.001) in STTh (STTh 1 = 1.06 mm, 117%; STTh 2 = 0.89 mm, 81%) were observed in the test group. Biopsy results showed angiogenesis and mature connective tissue covered by keratinized epithelium.


Within the limitations of this study, it could be concluded that mCM leads to a significant increase of peri-implant soft-tissue thickness, with good histological integration and replacement by soft tissue and may serve as an alternative to connective tissue grafting.


Augmentation; collagen matrix; connective tissue; tissue thickness; tissue volume

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