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AIDS Res Hum Retroviruses. 2017 Jul;33(7):740-744. doi: 10.1089/AID.2017.0049. Epub 2017 Apr 24.

Four Closely Related HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Identified in East China.

Li F1, Li Y1, Feng Y1, Hu J1, Ruan Y1, Xing H1, Shao Y1,2,3.

Author information

1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, China .
2 Center of Infectious Diseases, Peking University , Beijing, China .
3 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Hangzhou, China .


Five near full-length genomes of novel second-generation HIV-1 recombinant virus (JS150021, JS150029, JS150129, JS150132, and AH150183) were identified from five HIV-positive people in Jiangsu and Anhui province, east China. Phylogenic analyses showed that these five sequences are all composed of two well-established circulating recombinant forms (CRFs) CRF07_BC and CRF01_AE, grouped into four new discovered recombinant forms, which show several very similar but not identical recombinant breakpoints. The four recombinant forms are also identified to be a sort of family or related viruses, seems to be the results of different recombination events. The emergence of a serious new closely related CRF07_BC/CRF01_AE recombinant strain indicates the increasing complexity of sexual transmission of the HIV-1 epidemic in China.


HIV-1; NFLG; recombinant form

[Indexed for MEDLINE]

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