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J Clin Oncol. 2017 Mar 20;35(9):968-974. doi: 10.1200/JCO.2016.71.0806. Epub 2017 Feb 13.

Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome.

Author information

1
James A. Kennedy, University Health Network, Toronto, Ontario, Canada; James A. Kennedy and Benjamin L. Ebert, Brigham and Women's Hospital; and Benjamin L. Ebert, Dana-Farber Cancer Institute, Boston, MA.

Abstract

Myelodysplastic syndrome (MDS) is clonal disorder characterized by ineffective hematopoiesis and a tendency to evolve into acute myeloid leukemia (AML). Genetic studies have enabled the identification of a set of recurrently mutated genes central to the pathogenesis of MDS, which can be organized into a limited number of cellular processes, including RNA splicing, epigenetic and traditional transcriptional regulation, and signal transduction. The sequential accumulation of mutations drives disease evolution from asymptomatic clonal hematopoiesis to frank MDS, and, ultimately, to secondary AML. This detailed understanding of the molecular landscape of MDS, coupled with the emergence of cost- and time-effective methodologies for DNA sequencing has led to the introduction of genetic studies into the clinical realm. Here, we review recent advances in our genetic understanding of MDS, with a particular focus on the emerging role for mutational data in clinical management as a potential tool to assist in diagnosis, risk stratification, and therapeutic decision-making.

PMID:
28297619
PMCID:
PMC5455680
DOI:
10.1200/JCO.2016.71.0806
[Indexed for MEDLINE]
Free PMC Article

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