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Medicine (Baltimore). 2017 Mar;96(11):e6338. doi: 10.1097/MD.0000000000006338.

Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report.

Author information

1
aDepartment of Immunology, Oslo University Hospital, and K.G. Jebsen IRC, University of Oslo, Oslo, Norway. bDepartment of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University and Clinical Immunology and Transfusion Medicine, Region Skane, Lund, Sweden cResearch Laboratory, Nordland Hospital Bodø, and K.G. Jebsen TREC, University of Tromsø dDepartment of Obstetrics eDepartment of Haematology fDepartment of Immunology, Section of Medical Immunology, Oslo University Hospital, Oslo gCentre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim hDivision of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.

Abstract

RATIONALE:

Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an additional treatment option.

PATIENT CONCERNS, DIAGNOSIS AND INTERVENTIONS:

We present a pregnant patient treated with the C5-inhibitor eculizumab due to high risk of developing devastating APS-related complications. The complement inhibitory effects of the treatment were examined both in the patient and the premature infant.

OUTCOMES:

Complement activity in the mother recovered considerably faster than anticipated; however, no new thrombosis or CAPS developed during the last week of pregnancy or postpartum. Blood sampling from the umbilical vein and artery, and from the infant after delivery showed low complement activity; however, only 0.3% of the eculizumab concentration detected in the mother, consistent with low placental passage of eculizumab.

LESSONS:

The data underscore the importance of close monitoring of complement inhibition and individualizing dosage regimens in pregnant patients receiving eculizumab. We document how traditional functional complement activity tests cannot assess the effect of eculizumab in premature infants due to the very low levels of complement factors detected in this infant born in gestational week 33. Only trace amounts of eculizumab passed the placenta. In conclusion, complement C5 inhibition might be a safe candidate treatment option for APS during pregnancy and delivery, and additionally, enables prolongation of pregnancy with important weeks.

PMID:
28296762
PMCID:
PMC5369917
DOI:
10.1097/MD.0000000000006338
[Indexed for MEDLINE]
Free PMC Article

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