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BJOG. 2017 Sep;124(10):1501-1512. doi: 10.1111/1471-0528.14640. Epub 2017 May 13.

Epidemiology of uterine fibroids: a systematic review.

Author information

1
Division of Reproductive Endocrinology and Infertility, Departments of Obstetrics and Gynecology and Surgery, Mayo Clinic, Rochester, MN, USA.
2
Oxford PharmaGenesis, Tubney, Oxford, UK.
3
Epidemiology, Bayer AG, Berlin, Germany.

Abstract

BACKGROUND:

Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility.

OBJECTIVES:

To examine UF epidemiology and to evaluate the relative strengths of putative risk factors.

SEARCH STRATEGY:

MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015.

SELECTION CRITERIA:

Publications reporting relevant data from registries and other observational studies with over 1000 patients and single-centre studies with over 100 patients were selected.

DATA COLLECTION AND ANALYSIS:

Data on UF incidence, prevalence and associated risk factors were extracted from 60 publications.

MAIN RESULTS:

Wide ranges were reported in both UF incidence (217-3745 cases per 100 000 women-years) and prevalence (4.5-68.6%), depending on study populations and diagnostic methods. Black race was the only factor that was recurrently reported to increase UF risk, by two-threefold compared with white race. Eleven other factors affected UF risk to a magnitude similar to or greater than race. Age, premenopausal state, hypertension, family history, time since last birth, and food additive and soybean milk consumption increased UF risk; use of oral contraceptives or the injectable contraceptive depot medroxyprogesterone acetate, smoking in women with low body mass index and parity reduced UF risk.

CONCLUSIONS:

We identified 12 risk factors that play an important role in UF epidemiology. The UF risk factor with the strongest evidence is black race. High-quality prospective observational data are needed to improve our understanding of UF epidemiology, and thus its aetiology and optimal management.

TWEETABLE ABSTRACT:

Uterine fibroids occur in about 70% of women. Black race and 11 other factors affect uterine fibroid risk.

KEYWORDS:

Epidemiology; incidence; leiomyoma; prevalence; race; risk factors; uterine fibroids

PMID:
28296146
DOI:
10.1111/1471-0528.14640
[Indexed for MEDLINE]
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