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Clin Transplant. 2017 May;31(5). doi: 10.1111/ctr.12952. Epub 2017 Apr 17.

Relationship between pre-transplant physical function and outcomes after kidney transplant.

Author information

1
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
2
William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
3
Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
4
Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA.
5
Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Erratum in

Abstract

BACKGROUND:

Performance-based measures of physical function predict morbidity following non-transplant surgery. Study objectives were to determine whether physical function predicts outcomes after kidney transplant and assess how physical function changes post-transplant.

METHODS:

We conducted a prospective study involving living donor kidney transplants recipients at our center from May 2012 to February 2014. Physical function was measured using the Short Physical Performance Battery (SPPB [balance, chair stands, gait speed]) and grip strength testing. Initial length of stay (LOS), 30- day rehospitalizations, allograft function, and quality of life (QOL) were assessed.

RESULTS:

The majority of the 140 patients in our cohort had excellent pre-transplant physical function. In general, balance scores were more predictive of post-transplant outcomes than the SPPB. Decreased pre-transplant balance was independently associated with longer LOS and increased rehospitalizations but not with post-transplant QOL; 35% of patients experienced a clinically meaningful (≥ 1.0 m/s) improvement in gait speed 4 months post-transplant.

CONCLUSIONS:

Decreased physical function may be associated with longer LOS and rehospitalizations following kidney transplant. Further studies are needed to confirm this association. The lack of relationship between pre-transplant gait speed and outcomes in our cohort may represent a ceiling effect. More comprehensive measures, including balance testing, may be required for risk stratification.

KEYWORDS:

glomerular filtration rate (GFR); hospital readmission; kidney transplantation: living donor; quality of life (QOL)

PMID:
28295612
PMCID:
PMC5416778
DOI:
10.1111/ctr.12952
[Indexed for MEDLINE]
Free PMC Article

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