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J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):105-118. doi: 10.1176/appi.neuropsych.16080147. Epub 2017 Mar 15.

Outcome of Non-Invasive Brain Stimulation in Substance Use Disorders: A Review of Randomized Sham-Controlled Clinical Trials.

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From the Department of Psychiatry and Addictology, University Hospital of Dijon, Dijon, France (BT, J-C C-G); the INSERM U1093, Cognition, Action et Plasticité Sensorimotrice, University of Burgundy-Franche-Comté, Dijon, France (BT); the CHU de Nantes, Psychiatric Neuromodulation Unit, Addictology and Liaison Psychiatry Department, Nantes, France (AS, SB); the Laboratory of Canada Research Chair in Cognitive Neuroplasticity, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Quebec, Medical School, Laval University, Québec, Canada (SF); the Department of Psychiatry, University Hospital of Strasbourg, Strasbourg, France (LL); the Addiction Division, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland (SA, DZ); and the Addictive Disorders Research Group and Neuroscience Center, University of Geneva, Switzerland (SA, DZ).


Non-invasive brain stimulation (NIBS) might be a new approach to treat substance use disorders (SUD). A systematic review and critical analysis was performed to identify potential therapeutic effects of NIBS on addictions. A search of the Medline database was conducted for randomized sham-controlled trials using NIBS in the field of addiction and published until August 2016. Twenty-six studies in various SUD met the inclusion criteria. Converging evidence indicates that NIBS might be a promising mean to treat patients with alcohol and tobacco use disorders, by acting on craving reduction and other mechanisms such as improvement in cognitive dysfunctions.


Alcohol Abuse and Dependence; Drug/Substance Abuse; ECT

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