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Eur Ann Allergy Clin Immunol. 2017 Mar;49(2):75-79.

Vitamin D levels and allergic diseases. An italian cross-sectional multicenter survey.

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Departmental Unit of Allergology, Clinical Immunology & Pneumology, Fondazione Poliambulanza Hospital, Brescia, Italy.
Allergy and Respiratory Diseases IRCCS San Martino IST University of Genoa, Pad. Maragliano, L.go R. Benzi 10 16133 Genoa, Italy. Phone: +39 010 3538 933 Fax: +39 010 3538 904 E-mail:
ULSS 16, Distretto 1 Attività Allergologica Territoriale Convenzionata, Padua.
Azienda Ospedaliera Universitaria Arcispedale S. Anna, Ambulatorio Allergologico Struttura ad Alta Specializzazione in Patologia Immunoallergica Internistica, U.O di Clinica Medica, Ferrara.
Ospedale U. Parini, S.C. Medicina Interna, Ambulatorio di Allergologia e Immunologia Clinica, Aosta.
Allergy and Respiratory Diseases, IRCCS San Martino IST University of Genoa.
Azienda Ospedaliera, Università di Padova, U.O. di Medicina del Lavoro, Servizio di Allergologia, Padua.
INRCA-IRCCS, Casatenovo.
USL di Ravenna - Ospedale di Faenza, Unità di Alta Specializzazione di Allergologia, Faenza.
SOS Dipartimentale di Allergologia ASL Alessandria, Ospedale di Tortona.
Servizio di Allergologia Respiratoria, Ospedale S. Luigi di Orbassano, Turin.
Azienda Ospedaliera di Padova, Medicina del Lavoro e Malattie del Metabolismo, Padua.
Unità Dipartimentale di Allergologia, Fondazione Poliambulanza, Brescia.
U.O. di Pneumologia, Ospedale Civile di Voghera, Azienda Sanitaria Ospedaliera di Pavia.
S.O.S. Dipartimentale di Allergologia e Autoimmunità, Azienda Ospedaliera "Guglielmo da Saliceto", Piacenza.
Azienda Ospedaliera Universitaria di Parma, Allergologia ed Immunologia Clinica; U.O. di Medicina Interna e Lungodegenza Critica, Parma.
Azienda Ospedaliera Sant'Anna, Ambulatorio di Allergologia, Como.
Ospedale di Lonigo, Ambulatorio di Allergologia - Medicina Interna Convenzionata, Lonigo, Vicenza.
Azienda Ospedaliera di Bari - University of Bari.
Azienda Ospedaliera Universitaria Arcispedale S. Anna - Ambulatorio Allergologico Struttura ad Alta Specializzazione in Patologia Immunoallergica Internistica, U.O di Clinica Medica, Ferrara.
Azienda Ospedaliera Università di Novara, Medicina Interna 1 - S.C. Allergologia ed Immunologia Clinica, Ospedale San Giuliano, Novara.


Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases. Methods. The study was carried out in hospital- and private practice-based setting between October 2012 and March 2013, and 18 Centers participated. Only adult patients, with at least one positive skin prick test were included. The diagnostic procedures and the data collection were standardized among the centers. VD levels were assayed by the same laboratory test. Results. Three hundred and nine patients were enrolled (132 male, mean age 37.5 ± 17 years). Of them, 40% reported a positive family history for allergies (asthma / rhinitis). Rhinitis plus asthma was present in 47% of patients, atopic dermatitis in 15%, and a consistent clinical history of food allergy associated with positive skin tests was present in 25% of subjects. There was no significant association between VD level and age, sex, family history, rhinitis, or food allergy. VD levels were overall lower in patients with asthma and rhinitis, but without statistical significance. A significant difference in VD levels was detected between patient with or without atopic dermatitis. VD was not related to seasonal allergens, whereas a significant negative correlation was seen for house dust mite and dog dander. Conclusion. Our data, derived from a cross-sectional study involving only allergic patients, agree partially with the current literature. Nonetheless, the association between VD levels and allergies appeared weak. Studies involving larger samples would be required to better define the association between VD and allergies.


Vitamin D; allergens; allergic diseases; allergic rhinitis; atopic dermatitis; bronchial asthma; house dust mite

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