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Brain Behav. 2017 Feb 17;7(3):e00625. doi: 10.1002/brb3.625. eCollection 2017 Mar.

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease.

Author information

1
William S. Middleton Memorial Veterans HospitalMadisonWIUSA; Department of KinesiologyUniversity of Wisconsin School of EducationMadisonWIUSA.
2
Geriatric Research Education and Clinical CenterWilliam S. Middleton Memorial Veterans HospitalMadisonWIUSA; Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA; Wisconsin Alzheimer's InstituteUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA.
3
Department of KinesiologyUniversity of Wisconsin School of EducationMadisonWIUSA; Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA; Wisconsin Alzheimer's InstituteUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA.
4
William S. Middleton Memorial Veterans HospitalMadisonWIUSA; Department of KinesiologyIowa State University College of Human SciencesAmesIAUSA.
5
William S. Middleton Memorial Veterans HospitalMadisonWIUSA; Department of Family Medicine and Community HealthUniversity of WisconsinMadisonWIUSA.
6
William S. Middleton Memorial Veterans HospitalMadisonWIUSA; Geriatric Research Education and Clinical CenterWilliam S. Middleton Memorial Veterans HospitalMadisonWIUSA.
7
Division of Cardiology University of Wisconsin School of Medicine and Public Health Madison WI USA.
8
Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.
9
Department of Biostatistics & Medical Informatics University of Wisconsin School of Medicine and Public Health Madison WI USA.
10
Department of KinesiologyUniversity of Wisconsin School of EducationMadisonWIUSA; Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA.
11
Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA.
12
Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA; Wisconsin Alzheimer's InstituteUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA; Department of NeurologyUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA.
13
Wisconsin Alzheimer's Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA; Wisconsin Alzheimer's InstituteUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA.

Abstract

INTRODUCTION:

Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).

METHODS:

Eighty-six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T-1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).

RESULTS:

There were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.

SUMMARY:

These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.

KEYWORDS:

exercise; APOE‐e4; cognition; family history; physical activity

PMID:
28293467
PMCID:
PMC5346514
DOI:
10.1002/brb3.625
[Indexed for MEDLINE]
Free PMC Article

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