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Nat Rev Mol Cell Biol. 2017 Jun;18(6):375-388. doi: 10.1038/nrm.2017.11. Epub 2017 Mar 15.

Planar cell polarity in development and disease.

Author information

1
Department of Molecular Biosciences, Patterson Labs, 2401 Speedway, The University of Texas at Austin, Austin, Texas 78712, USA.

Abstract

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by multiple global cues, including gradients of gene expression, gradients of secreted WNT ligands and anisotropic tissue strain. These cues guide the dynamic, subcellular enrichment of PCP proteins, which can self-assemble into mutually exclusive complexes at opposite sides of a cell. Endocytosis, endosomal trafficking and degradation dynamics of PCP components further regulate planar tissue patterning. This polarization propagates throughout the whole tissue, providing a polarity axis that governs collective morphogenetic events such as the orientation of subcellular structures and cell rearrangements. Reflecting the necessity of polarized cellular behaviours for proper development and function of diverse organs, defects in PCP have been implicated in human pathologies, most notably in severe birth defects.

PMID:
28293032
PMCID:
PMC5826606
DOI:
10.1038/nrm.2017.11
[Indexed for MEDLINE]
Free PMC Article

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