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Physiol Rep. 2017 Mar;5(5). pii: e13095. doi: 10.14814/phy2.13095.

Evidence for a histaminergic input from the ventral tuberomammillary nucleus to the solitary tract nucleus involved in arterial pressure regulation.

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Department of Physiology, School of Health and Sports Science Juntendo University, Chiba, Japan.
Department of Biology, Faculty of Science Ochanomizu University, Tokyo, Japan.
Department of Therapeutic Health Promotion, Kansai University of Health Sciences, Osaka, Japan.
Department of Physiology, Wakayama Medical University School of Medicine, Wakayama, Japan.
Department of Physiology, Graduate School of Health and Sports Science Juntendo University, Chiba, Japan


The tuberomammillary nucleus (TMN) of the posterior hypothalamus has a high density of histaminergic neurons, the projection fibers of which are present in many areas of the brain, including the nucleus tractus solitarius (NTS), which controls arterial pressure (AP). In this study, we investigated whether the TMN-NTS pathway is involved in central cardiovascular regulation. Bicuculline, a gamma-aminobutyric acid type A (GABAA) receptor antagonist, was microinjected into the ventral TMN of anesthetized rats and its effects on AP and heart rate (HR) were observed. We also evaluated the effect of cetirizine, an H1 receptor antagonist, microinjected into the NTS on cardiovascular responses induced by electrical stimulation of the TMN Both AP and HR increased following bicuculline microinjection into the ventral TMN Similar pressor and tachycardic responses were observed after electrical stimulation of the ventral TMN Microinjection of cetirizine into the NTS partially inhibited the pressor response but had no effect on HR Finally, the treadmill test was associated with a high level of c-Fos expression in both ventral TMN and NTS neurons. These results suggest that the TMN-NTS pathway is involved in regulation of AP, presumably under a high-arousal phase, such as that during exercise.


Arterial pressure; histamine; nucleus tractus solitarius; tuberomammillary nucleus

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