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Biomacromolecules. 2017 Apr 10;18(4):1419-1425. doi: 10.1021/acs.biomac.7b00146. Epub 2017 Mar 28.

Effect of Chemical and Physical Properties on the In Vitro Degradation of 3D Printed High Resolution Poly(propylene fumarate) Scaffolds.

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The Ohio State University , Department of Plastic Surgery, 460 West 12th Avenue, Room 388, Columbus, Ohio 43210, United States.
Youngstown State University , Department of Mechanical and Industrial Engineering, 1 University Plaza, Youngstown, Ohio 44555, United States.
The University of Akron , Department of Polymer Science, 170 University Avenue, Akron, Ohio 44325-3909, United States.


Two distinct molecular masses of poly(propylene fumarate) (PPF) are combined with an additive manufacturing process to fabricate highly complex scaffolds possessing controlled chemical properties and porous architecture. Scaffolds were manufactured with two polymer molecular masses and two architecture styles. Degradation was assessed in an accelerated in vitro environment. The purpose of the degradation study is not to model or mimic in vivo degradation, but to efficiently compare the effect of modulating scaffold properties. This is the first study addressing degradation of chain-growth synthesized PPF, a process that allows for considerably more control over molecular mass distribution. It demonstrates that, with greater process control, not only is scaffold fabrication reproducible, but the mechanical properties and degradation kinetics can be tailored by altering the physical properties of the scaffold. This is a clear step forward in using PPF to address unmet medical needs while meeting regulatory demands and ultimately obtaining clinical relevancy.

[Indexed for MEDLINE]

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