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Sci Data. 2017 Mar 14;4:170010. doi: 10.1038/sdata.2017.10.

Enhancing studies of the connectome in autism using the autism brain imaging data exchange II.

Author information

1
The Child Study Center at NYU Langone Medical Center, New York, New York 10016, USA.
2
Child Mind Institute, New York, New York 10022, USA.
3
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, New York 10962, USA.
4
KU Leuven, Department of Rehabilitation Sciences, Neuromotor Rehabilitation Research Group 3000, Leuven, Belgium.
5
Division of Neuroradiology, University of Utah, Salt Lake City, Utah 84112, USA.
6
Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah 84116, USA.
7
The Brain Institute at the University of Utah, Salt Lake City, Utah 84116, USA.
8
Department of Bioengineering, University of Utah, Salt Lake City, Utah 84116, USA.
9
Olin Neuropsychiatry Research Center, The Institute of Living, Hartford Hospital, Hartford, Connecticut 06102, USA.
10
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
11
Neural Control of Movement Lab, ETH Zürich, Zürich 8092, Switzerland.
12
Neuroimaging Research, Barrow Neurological Institute, Phoenix, Arizona 85013, USA.
13
Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, 75019 Paris, France.
14
Human Genetics and Cognitive Functions, Institut Pasteur, 75015 Paris, France.
15
Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, 3015 Rotterdam, Netherlands.
16
Center for Cognitive Neuroscience, UCLA, Los Angeles, California 90095, USA.
17
Department of Psychiatry &Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095, USA.
18
Interdepartmental Neuroscience Program, UCLA, Los Angeles, California 90095, USA.
19
David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA.
20
Department of Speech and Hearing Science, Arizona State University, Tempe, Arizona 85004, USA.
21
Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 47405, USA.
22
Ahmanson-Lovelace Brain Mapping Center, UCLA, Los Angeles, California 90095, USA.
23
Behavioral Neuroscience Department, Oregon Health &Science University, Portland, Oregon 97239, USA.
24
Psychiatry Department, Oregon Health &Science University, Portland, Oregon 97239, USA.
25
Advanced Imaging Research Center, Oregon Health &Science University, Portland, Oregon 97239, USA.
26
Department of Psychology, San Diego State University, San Diego, California 92182, USA.
27
Department of Psychiatry, School of Medicine, Trinity Centre for Health Science, St James's Hospital, Dublin 8, Ireland.
28
Trinity Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
29
Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA.
30
Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
31
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
32
Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA.
33
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
34
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.
35
UC Davis Department of Psychiatry and Behavioral Science, California 95817, USA.
36
UC Davis MIND Institute, Sacramento, California 95817, USA.
37
Children's Research Institute, Children's National Medical Center, Washington, District Of Columbia 20010, USA.
38
Department of Psychology, Georgetown University, Washington, District Of Columbia 20010, USA.
39
Center for Autism and the Developing Brain, Weill Cornell Medical College, White Plains, New York 10605, USA.
40
Department of Psychiatry, University of California San Francisco, San Francisco, California 94103, USA.

Abstract

The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions. The combination of ABIDE I and ABIDE II provides investigators with 2156 unique cross-sectional datasets allowing selection of samples for discovery and/or replication. This sample size can also facilitate the identification of neurobiological subgroups, as well as preliminary examinations of sex differences in ASD. Additionally, ABIDE II includes a range of psychiatric variables to inform our understanding of the neural correlates of co-occurring psychopathology; 284 diffusion imaging datasets are also included. It is anticipated that these enhancements will contribute to unraveling key sources of ASD heterogeneity.

PMID:
28291247
PMCID:
PMC5349246
DOI:
10.1038/sdata.2017.10
[Indexed for MEDLINE]
Free PMC Article

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