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Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b.

Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.

Author information

1
Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, Laboratoire de Chimie et Biologie des Métaux, BioCat, UMR 5249, France and CEA-Grenoble, DRF/BIG/CBM, F-Grenoble, France. stephane.menage@cea.fr.
2
Université Grenoble Alpes, Laboratoire de Chimie et Biologie des Métaux, BioCE, F-Grenoble, France and CNRS, UMR CEA, IBS, F-38044 Grenoble, France.
3
Inorganic Chemistry, Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM), University of Erlangen-Nuremberg, Egerlandstraße 1, 91058 Erlangen, Germany.

Abstract

Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced α-hydroxy-β-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h-1).

PMID:
28289745
DOI:
10.1039/c6cc08873b
[Indexed for MEDLINE]

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