[Effect of human interferons on cAMP phosphodiesterase activity in a culture of human ovarian carcinoma cells (CaOv)]

Mol Gen Mikrobiol Virusol. 1987 Sep:(9):44-6.
[Article in Russian]

Abstract

Crude and purified human interferons of alpha type exerted 2 step inhibition of cAMP phosphodiesterase activity in CaOv cells: in 4 and 24 hours after cells treatment with interferon. The maximal inhibition was obtained in response to interferon doses 1200-2000 IU/ml. In contrast to natural interferons the human alpha 2 recombinant interferon (20-25000 IU/ml) did not inhibit the cAMP phosphodiesterase activity in CaOv cells.

Publication types

  • English Abstract

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / metabolism*
  • Cyclic AMP / biosynthesis
  • Enzyme Activation
  • Female
  • Humans
  • Interferon Type I / pharmacology*
  • Ovarian Neoplasms / enzymology
  • Recombinant Proteins / pharmacology
  • Tumor Cells, Cultured / enzymology*

Substances

  • Interferon Type I
  • Recombinant Proteins
  • Cyclic AMP
  • 3',5'-Cyclic-AMP Phosphodiesterases