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Behav Brain Res. 2017 May 30;326:291-302. doi: 10.1016/j.bbr.2017.03.011. Epub 2017 Mar 10.

Effects of prenatal exposure to WIFI signal (2.45GHz) on postnatal development and behavior in rat: Influence of maternal restraint.

Author information

1
University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, Jarzouna 7021, Tunisia.
2
University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, Jarzouna 7021, Tunisia; University of Tunis El Manar, Higher Institute of Applied Biological Sciences of Tunis, 9, Rue Zouhair Essafi, 1006 Tunis, Tunisia. Electronic address: mohamed.ammari@fsb.rnu.tn.

Abstract

The present study was carried out to investigate the potential combined influence of maternal restraint stress and 2.45GHz WiFi signal exposure on postnatal development and behavior in the offspring of exposed rats. 24 pregnant albino Wistar rats were randomly assigned to four groups: Control, WiFi-exposed, restrained and both WiFi-exposed and restrained groups. Each of WiFi exposure and restraint occurred 2h/day along gestation till parturition. The pups were evaluated for physical development and neuromotor maturation. Moreover, elevated plus maze test, open field activity and stationary beam test were also determined on postnatal days 28, 30 and 31, respectively. After behavioral tests, the rats were anesthetized and their brains were removed for biochemical analysis. Our main findings showed no detrimental effects on gestation progress and outcomes at delivery in all groups. Subsequently, WiFi and restraint, per se and mainly in concert altered physical development of pups with slight differences between genders. Behaviorally, the gestational WiFi irradiation, restraint and especially the associated treatment affected the neuromotor maturation mainly in male progeny. At adult age, we noticed anxiety, motor deficit and exploratory behavior impairment in male offspring co-exposed to WiFi radiation and restraint, and in female progeny subjected to three treatments. The biochemical investigation showed that, all three treatments produced global oxidative stress in brain of both sexes. As for serum biochemistry, phosphorus, magnesium, glucose, triglycerides and calcium levels were disrupted. Taken together, prenatal WiFi radiation and restraint, alone and combined, provoked several behavioral and biochemical impairments at both juvenile and adult age of the offspring.

KEYWORDS:

2.45GHz WiFi signal; Behavior; Neurodevelopment; Offspring; Oxidative stress; Prenatal; Restraint; Serum biochemistry

PMID:
28288806
DOI:
10.1016/j.bbr.2017.03.011
[Indexed for MEDLINE]

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