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Elife. 2017 Mar 14;6. pii: e22001. doi: 10.7554/eLife.22001.

Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance.

Author information

1
The Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
2
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom.
3
Developmental Imaging and Biophysics Section, UCL Institute of Child Health, University College London, London, United Kingdom.

Abstract

Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavior in humans is limited. Here we applied transcranial alternating current stimulation (tACS) to exogenously modulate oscillatory activity in a right frontoparietal network that supports WM. Externally induced synchronization improved performance when cognitive demands were high. Simultaneously collected fMRI data reveals tACS effects dependent on the relative phase of the stimulation and the internal cognitive processing state. Specifically, synchronous tACS during the verbal WM task increased parietal activity, which correlated with behavioral performance. Furthermore, functional connectivity results indicate that the relative phase of frontoparietal stimulation influences information flow within the WM network. Overall, our findings demonstrate a link between behavioral performance in a demanding WM task and large-scale brain synchronization.

KEYWORDS:

Working memory; brain networks; brain stimulation; human; neuroscience; oscillations; synchronization; tACS

PMID:
28288700
PMCID:
PMC5349849
DOI:
10.7554/eLife.22001
[Indexed for MEDLINE]
Free PMC Article

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