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J Virol. 1988 Mar;62(3):1097-100.

Variation of R1 repeated sequence present in open reading frame 11 of varicella-zoster virus strains.

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  • 1Department of Microbiology, School of Hygienic Sciences, Kitasato University, Kanagawa, Japan.


We molecularly cloned the tandem direct reiteration (R1) present in open reading frame (ORF) 11 from three independent strains of varicella-zoster virus. Comparison of the R1 sequences among varicella-zoster virus strains revealed that, although the portion of R1 near the 5' terminus of ORF 11 was conserved among strains, the 3'-terminal portion varied remarkably. This variation was due to the different arrangement of two elements (A and B) and a segment produced by fusion of A and B and to a single-base change in the A element. Since the difference in the size of R1 among strains was a multiple of 3 base pairs, the variation in R1 caused no frame shift in ORF 11.

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