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Cell Immunol. 2017 May;315:1-10. doi: 10.1016/j.cellimm.2016.12.005. Epub 2016 Dec 26.

Toll-like receptors as a key regulator of mesenchymal stem cell function: An up-to-date review.

Author information

1
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Shamsk@tbzmed.ac.ir.

Abstract

Understanding the role of toll-like receptors (TLRs) in the immunomodulation potential, differentiation, migration, and survival of mesenchymal stem cells (MSCs) is absolutely vital to fully exploiting their MSC-based therapeutic potential. Furthermore, through recognition of exogenous or endogenous ligands produced upon injury, TLRs have been linked to allograft rejection and maintenance of chronic inflammatory diseases, including Crohn's disease, rheumatoid arthritis. Characterizing the effect of TLRs in biological control of MSCs fate and function could improve our knowledge about the MSC-based cell therapy and immunotherapy. In this paper, we outline the impacts of TLR activation and mechanisms on MSCs immunomodulatory functions, differentiation, migration, and survivability. Moreover, we indicate that the expression patterns of TLRs in MSCs from different sources.

KEYWORDS:

Immunology; Mechanism; Mesenchymal stem cell; Therapeutic use; Toll-like receptor

PMID:
28284487
DOI:
10.1016/j.cellimm.2016.12.005
[Indexed for MEDLINE]

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