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J Neuroimmunol. 2017 Apr 15;305:128-130. doi: 10.1016/j.jneuroim.2017.01.018. Epub 2017 Feb 2.

Confirmed case of levamisole-associated multifocal inflammatory leukoencephalopathy in a cocaine user.

Author information

1
University of California, San Francisco, Department of Neurology, San Francisco, CA, USA. Electronic address: Jeffrey.vitt@ucsf.edu.
2
University of California, San Francisco, Department of Neurology, San Francisco, CA, USA.
3
Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.

Abstract

Levamisole is a common adulterant in cocaine and has previously been associated with a variety of serious complications including multifocal inflammatory leukoencephalopathy (MIL). There have been several reports of MIL in patients taking cocaine and, though suspected, the presence of levamisole was not confirmed. We present a case of a 63-year-old woman presenting with stupor and spastic quadraparesis found to have urine positive for cocaine and levamisole. An MRI brain revealed innumerable FLAIR hyperintensities with restricted diffusion and incomplete ring-enhancement. This is the first case to confirm the presence of levamisole in a patient with MIL associated with cocaine use.

PMID:
28284332
DOI:
10.1016/j.jneuroim.2017.01.018
[Indexed for MEDLINE]

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