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Int J Tuberc Lung Dis. 2017 Apr 1;21(4):425-431. doi: 10.5588/ijtld.16.0434.

Mycobacterium tuberculosis infection among persons who inject drugs in San Diego, California.

Author information

1
Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego, San Diego.
2
Division of Global Public Health, Department of Medicine, University of California San Diego, San Diego.
3
Division of Pulmonology, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, San Diego, California, USA.

Abstract

BACKGROUND:

Persons who inject drugs (PWID) might be at increased risk for Mycobacterium tuberculosis infection and reactivation of latent tuberculous infection (LTBI) due to their injection drug use.

OBJECTIVES:

To determine prevalence and correlates of M. tuberculosis infection among PWID in San Diego, California, USA.

METHODS:

PWID aged 18 years underwent standardized interviews and serologic testing using an interferon-gamma release assay (IGRA) for LTBI and rapid point-of-care assays for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections. Independent correlates of M. tuberculosis infection were identified using multivariable log-binomial regression.

RESULTS:

A total of 500 participants met the eligibility criteria. The mean age was 43.2 years (standard deviation 11.6); most subjects were White (52%) or Hispanic (30.8%), and male (75%). Overall, 86.7% reported having ever traveled to Mexico. Prevalence of M. tuberculosis infection was 23.6%; 0.8% were co-infected with HIV and 81.7% were co-infected with HCV. Almost all participants (95%) had been previously tested for M. tuberculosis; 7.6% had been previously told they were infected. M. tuberculosis infection was independently associated with being Hispanic, having longer injection histories, testing HCV-positive, and correctly reporting that people with 'sleeping' TB cannot infect others.

CONCLUSIONS:

Strategies are needed to increase awareness about and treatment for M. tuberculosis infection among PWID in the US/Mexico border region.

PMID:
28284258
DOI:
10.5588/ijtld.16.0434
[Indexed for MEDLINE]

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