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Environ Sci Pollut Res Int. 2017 Apr;24(11):10621-10629. doi: 10.1007/s11356-017-8743-9. Epub 2017 Mar 10.

Hepatic transcriptomic responses in mice exposed to arsenic and different fat diet.

Author information

1
State Key Laboratory of Pollutant Control and Resource Reuse, School of the Environment, Nanjing University, Xianlin Campus, 163 Xianlin Avenue, Nanjing, 210023, People's Republic of China.
2
State Key Laboratory of Pollutant Control and Resource Reuse, School of the Environment, Nanjing University, Xianlin Campus, 163 Xianlin Avenue, Nanjing, 210023, People's Republic of China. bwu@nju.edu.cn.

Abstract

Chronic exposure to inorganic arsenic (iAs) or a high-fat diet (HFD) can produce liver injury. However, effects of HFD on risk assessment of iAs in drinking water are unclear. In this study, we examined how HFD and iAs interact to alter iAs-induced liver injury in C57BL/6 mice. Mice fed low-fat diet (LFD) or HFD were exposed to 3 mg/L iAs or deionized water for 10 weeks. Results showed that HFD changed intake and excretion of iAs by mice. Then, HFD increased the amount of iAs-induced hepatic DNA damage and amplified changes in pathways related to cell death and growth, signal transduction, lipid metabolism, and insulin signaling. Compared to gene expression profiles caused by iAs alone or HFD alone, insulin signaling pathway might play important roles in the interactive effects of iAs and HFD. Our data suggest that HFD increases sensitivity of mice to iAs in drinking water, resulting in increased hepatotoxicity. This study highlight that HFD might enhance the risk of iAs hepatotoxicity in iAs-polluted regions. The diet should be considered during risk assessment of iAs in drinking water.

KEYWORDS:

Arsenic; Drinking water; Hepatotoxicity; High-fat diet; Mice; Transcriptomic profiles

PMID:
28283972
DOI:
10.1007/s11356-017-8743-9
[Indexed for MEDLINE]

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