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Curr Opin Neurobiol. 2017 Aug;45:16-23. doi: 10.1016/j.conb.2017.02.011. Epub 2017 Mar 7.

Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes.

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Department of Biomedicine, Pharmazentrum, University of Basel, Klingelbergstr. 50/70, CH-4056 Basel, Switzerland.
Institute of Physiology, Faculty of Medicine, University of Freiburg, Hermann-Herder-Straße 7, 79104 Freiburg, Germany; Center for Biological Signaling Studies (BIOSS), Schänzlestraße 18, 79104 Freiburg, Germany. Electronic address:


Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks of these two types of neurotransmitter receptors in the brain (termed receptor proteomes). This provided the opportunity to match receptor proteomes with receptor physiology and to study the structural organization, regulation and function of native receptor complexes in an unprecedented manner. In this review we discuss the principles of receptor architecture and regulation emerging from the functional characterization of the proteomes of AMPA and GABAB receptors. We also highlight progress in unraveling the role of unexpected protein components for receptor physiology.

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