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Cell Res. 2017 May;27(5):600-601. doi: 10.1038/cr.2017.30. Epub 2017 Mar 10.

Moving towards totipotency without a single miR-acle.

Author information

1
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

Abstract

Totipotency is the ability of a single cell to form an entire embryo, including extraembryonic tissues, an ability we have yet to recapitalize, in vitro. In a recent paper published in Science, Choi et al. showed that pluripotent stem cells lacking microRNA miR-34a, have an expanded cell fate potential allowing differentiation into not only embryonic but also extraembryonic lineages.

PMID:
28281537
PMCID:
PMC5520849
DOI:
10.1038/cr.2017.30
[Indexed for MEDLINE]
Free PMC Article

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