Format

Send to

Choose Destination
Pflugers Arch. 2017 Jun;469(5-6):593-610. doi: 10.1007/s00424-017-1964-4. Epub 2017 Mar 9.

Neurobiology of local and intercellular BDNF signaling.

Author information

1
Institute of Clinical Neurobiology, University Hospital, University of Würzburg, 97078, Würzburg, Germany.
2
Centre for Integrative Biology (CIBIO), University of Trento, 38123, Povo, TN, Italy.
3
European Brain Research Institute (EBRI) "Rita Levi-Montalcini", 00143, Rome, Italy.
4
Institute of Clinical Neurobiology, University Hospital, University of Würzburg, 97078, Würzburg, Germany. Blum_R@UKW.de.

Abstract

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase TrkB, link neuronal growth and differentiation with synaptic plasticity. For this reason, interference with BDNF signaling has emerged as a promising strategy for potential treatments in psychiatric and neurological disorders. In many brain circuits, synaptically released BDNF is essential for structural and functional long-term potentiation, two prototypical cellular models of learning and memory formation. Recent studies have revealed an unexpected complexity in the synaptic communication of mature BDNF and its precursor proBDNF, not only between local pre- and postsynaptic neuronal targets but also with participation of glial cells. Here, we consider recent findings on local actions of the BDNF family of ligands at the synapse and discuss converging lines of evidence which emerge from per se conflicting results.

KEYWORDS:

Anxiety disorders; BDNF; Long-term potentiation; Signaling; Synaptic localization; Synaptic plasticity; TrkB

PMID:
28280960
PMCID:
PMC5438432
DOI:
10.1007/s00424-017-1964-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center