Format

Send to

Choose Destination
Breast Cancer (Dove Med Press). 2017 Feb 24;9:61-65. doi: 10.2147/BCTT.S128777. eCollection 2017.

Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells.

Author information

1
Department of Bioengineering.
2
Department of Bioengineering; Department of Surgery; McGowan Institute of Regenerative Medicine.
3
Department of Bioengineering; McGowan Institute of Regenerative Medicine; Department of Pathology; Department of Cell Biology; Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer.

KEYWORDS:

blood cell traffic; breast cancer; drag-reducing polymer; extravasation; hemodynamics; metastasis; microvessels

Supplemental Content

Full text links

Icon for Dove Medical Press Icon for PubMed Central
Loading ...
Support Center