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Ther Clin Risk Manag. 2017 Feb 27;13:279-285. doi: 10.2147/TCRM.S123199. eCollection 2017.

High expression of Aldolase A predicts poor survival in patients with clear-cell renal cell carcinoma.

Author information

1
Department of Kidney Transplantation.
2
Department of Obstetrics and Genecology, The Third Affiliated Hospital of Sun Yat-sen University.
3
Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Abstract

BACKGROUND:

Aldolase A (ALDOA) is a glycolytic enzyme that drives the glycolytic metabolic pathway in mammalian cells. The overexpression of ALDOA was observed in a variety of cancers including clear-cell renal cell carcinoma (ccRCC). However, little was known about the clinicopathological significance and prognostic value of ALDOA in ccRCC patients.

METHODS:

The expression of ALDOA was detected using immunohistochemical staining in 162 formalin-fixed, paraffin-embedded ccRCC sections. Prognostic outcomes correlated with ALDOA were examined using Kaplan-Meier analysis and the Cox proportional hazards model.

RESULTS:

In patients with ccRCC, increased cytoplasmic ALDOA expression was positively associated with tumor size (P=0.021), TNM stages (P=0.034), lymph node metastasis (P=0.020), and overall survival (OS) (P<0.001). Kaplan-Meier analysis showed that high cytoplasmic expression of ALDOA was associated with a statistically significant lower OS (P<0.001). Multivariate analysis demonstrated that ALDOA expression was an independent and significant prognostic factor (HR =3.561, 95% CI =1.715-7.396, P=0.001). ALDOA expression was not associated with significant prognostic deference in the subgroups of TNM stage I patients or pT1 patients.

CONCLUSION:

Our results suggest that ALDOA expression is an independent prognostic factor for OS in patients with ccRCC.

KEYWORDS:

Aldolase A; glycolysis; prognosis; renal carcinoma

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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