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Clin Interv Aging. 2017 Feb 28;12:445-452. doi: 10.2147/CIA.S130690. eCollection 2017.

Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years.

Author information

1
Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Abstract

OBJECTIVES:

We aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males >50 years of age.

METHODS:

A cross-sectional study of 385 Chinese males >50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA <4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA <6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites.

RESULTS:

Serum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA.

CONCLUSION:

Our results provide epidemiological evidence in Chinese Han males aged >50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males >50 years of age.

KEYWORDS:

T-value; Z-value; bone turnover marker; parathyroid hormone

PMID:
28280317
PMCID:
PMC5340242
DOI:
10.2147/CIA.S130690
[Indexed for MEDLINE]
Free PMC Article

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