A Sour Relationship between BabA and Lewis b

Masanori Hatakeyama

doi:10.1016/j.chom.2017.02.014

A Sour Relationship between BabA and Lewis b

Cell Host Microbe. 2017 Mar 8;21(3):318-320. doi: 10.1016/j.chom.2017.02.014.

Author

Masanori Hatakeyama¹

Affiliation

¹ Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Max Planck - The University of Tokyo Center for Integrative Inflammology, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama 332-0012, Japan. Electronic address: mhata@m.u-tokyo.ac.jp.

PMID: 28279343
DOI: 10.1016/j.chom.2017.02.014

Abstract

Helicobacter pylori survives in the hostile acidic environment of the stomach through extensive adaptation. In this issue of Cell Host & Microbe, Bugaytsova et al. (2017) report an acid-responsive, reversible adherence of H. pylori BabA to the gastric mucosa, the strength of which is tuned by dynamic BabA adaptation.

Publication types

Comment

MeSH terms

Adhesins, Bacterial
Bacterial Adhesion
Gastric Mucosa / immunology
Helicobacter Infections*
Helicobacter pylori
Humans
Lewis Blood Group Antigens*

Substances

Adhesins, Bacterial
Lewis Blood Group Antigens