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Cell Host Microbe. 2017 Mar 8;21(3):312-314. doi: 10.1016/j.chom.2017.02.011.

Unsweetened IgG Is Bad for Dengue Patients.

Author information

1
Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.

Abstract

Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients may enhance disease severity.

KEYWORDS:

IgG; dengue; dengue hemorrhagic fever; enhancement of disease; fucosylation of IgG; platelet depletion

PMID:
28279340
DOI:
10.1016/j.chom.2017.02.011
[Indexed for MEDLINE]
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