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Cell Host Microbe. 2017 Mar 8;21(3):297-300. doi: 10.1016/j.chom.2017.02.003.

Trained Immunity: An Ancient Way of Remembering.

Author information

1
Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: mihai.netea@radboudumc.nl.
2
Department of Internal Medicine, Radboud University Medical Centre, PO box 9101, 6500HB Nijmegen, the Netherlands. Electronic address: jos.vandermeer@radboudumc.nl.

Abstract

The innate arm of the immune system has generally been regarded as primitive and non-specific and, in contrast to adaptive immunity, not to possess memory. Here we review the growing body of evidence that innate immunity has an important capacity to adapt, a de facto innate immune memory (also termed trained immunity), and this provides broad protection against infections.

KEYWORDS:

cytokines; infections; innate immune memory; trained immunity; vertebrate immunity

PMID:
28279335
DOI:
10.1016/j.chom.2017.02.003
[Indexed for MEDLINE]
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