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Cell Host Microbe. 2017 Mar 8;21(3):290-293. doi: 10.1016/j.chom.2017.01.016.

DAI Another Way: Necroptotic Control of Viral Infection.

Author information

1
Department of Molecular Biosciences, LaMontagne Center for Infectious Disease, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: upton@austin.utexas.edu.
2
Department of Microbiology, Immunology, & Molecular Genetics, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA.

Abstract

Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

PMID:
28279333
DOI:
10.1016/j.chom.2017.01.016
[Indexed for MEDLINE]
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