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Artif Cells Nanomed Biotechnol. 2018 Feb;46(1):75-81. doi: 10.1080/21691401.2017.1290648. Epub 2017 Feb 23.

Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment.

Author information

1
a Department of Biotechnology , University Campus 2, University of Guilan , Rasht , Iran.
2
b Faculty of Agricultural Sciences , University of Guilan , Rasht , Iran.
3
c Materials and Energy Research Center , Tehran , Iran.
4
d Department of Medical genetics , Iran University of Medical Sciences , Tehran , Iran.

Abstract

Mesoporous silica nanocarriers as accommodate drug molecule capsules were synthesized and capped by chitosan natural polymer. This nanocarrier acts as a pH-responsive shield to increase the solubility and improvement of anticancer properties of curcumin against U87MG glioblastoma cancer cell line. The encapsulation efficiency and drug-loading content were measured 88.1 ± 4.76% and 8.81 ± 0.47%, respectively. The curcumin release from the CS-MCM-41 was slow and sustained at low pH (42.72 ± 2.29%) compared to the environment pH (19.54 ± 1.36%) in 96 h. The MTT evaluations showed that IC50 after 72 h treatment with free curcumin and curcumin-loaded CS-MCM-41 were 15.20 and 5.21 μg/mL (p <0.05). respectively.

KEYWORDS:

Mesoporous silica; cancer therapy; chitosan; drug delivery; nanomedicine; pH sensitive

PMID:
28278578
DOI:
10.1080/21691401.2017.1290648
[Indexed for MEDLINE]

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