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Psychoneuroendocrinology. 2017 May;79:116-121. doi: 10.1016/j.psyneuen.2017.02.012. Epub 2017 Feb 16.

Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study.

Author information

1
Women's Mood Disorders Center, Johns Hopkins University School of Medicine, United States. Electronic address: lmosborne@jhmi.edu.
2
Women's Mood Disorders Center, Johns Hopkins University School of Medicine, United States.

Abstract

Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

KEYWORDS:

Anxiety; Depression; Hormones; Postpartum; Pregnancy; Reproductive

PMID:
28278440
PMCID:
PMC5420429
DOI:
10.1016/j.psyneuen.2017.02.012
[Indexed for MEDLINE]
Free PMC Article

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