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PLoS Pathog. 2017 Mar 9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. eCollection 2017 Mar.

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

Author information

1
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
2
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America.
3
Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.
4
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.
5
Department of Obstetrics & Gynecology, Oregon Health and Science University, Portland, Oregon, United States of America.
6
Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.
7
Clinical Medicine Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, Oregon, United States of America.
8
UPMC Presbyterian Hospital, Division of Neuropathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Abstract

Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcephaly and other developmental abnormalities in the fetus. We report herein the results of ZIKV infection of adult rhesus macaques. Following subcutaneous infection, animals developed transient plasma viremia and viruria from 1-7 days post infection (dpi) that was accompanied by the development of a rash, fever and conjunctivitis. Animals produced a robust adaptive immune response to ZIKV, although systemic cytokine response was minimal. At 7 dpi, virus was detected in peripheral nervous tissue, multiple lymphoid tissues, joints, and the uterus of the necropsied animals. Notably, viral RNA persisted in neuronal, lymphoid and joint/muscle tissues and the male and female reproductive tissues through 28 to 35 dpi. The tropism and persistence of ZIKV in the peripheral nerves and reproductive tract may provide a mechanism of subsequent neuropathogenesis and sexual transmission.

PMID:
28278237
PMCID:
PMC5344528
DOI:
10.1371/journal.ppat.1006219
[Indexed for MEDLINE]
Free PMC Article

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