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Fly (Austin). 2017 Jul 3;11(3):224-238. doi: 10.1080/19336934.2017.1295189. Epub 2017 Feb 16.

Methods to investigate the structure and connectivity of the nervous system.

Author information

1
a Division of Biology and Biological Engineering , California Institute of Technology , Pasadena , CA , USA.
2
b Department of Cell Biology, School of Science , University of Extremadura , Badajoz , Spain.

Abstract

Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.

KEYWORDS:

brain circuit; connectomics; neuron; synapse; wiring diagram

PMID:
28277925
PMCID:
PMC5552278
DOI:
10.1080/19336934.2017.1295189
[Indexed for MEDLINE]
Free PMC Article

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