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Schizophr Res. 2017 Apr;182:42-48. doi: 10.1016/j.schres.2016.10.030. Epub 2016 Oct 27.

Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis.

Author information

1
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: regitzewils@gmail.com.
2
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: dittegotfredsen@gmail.com.
3
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark. Electronic address: carsten.hjorthoej@regionh.dk.
4
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark; Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: Stephen.01.Austin@regionh.dk.
5
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: nikolai.albert@regionh.dk.
6
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: gry_secher@yahoo.dk.
7
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark. Electronic address: Anne.Amalie.Elgaard.Thorup@regionh.dk.
8
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark. Electronic address: nielmors@rm.dk.
9
Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark. Electronic address: mn@dadlnet.dk.

Abstract

BACKGROUND:

Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up.

METHODS:

The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication.

FINDINGS:

61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse.

CONCLUSION:

Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.

KEYWORDS:

Antipsychotic medication; First episode psychosis; Long-term outcome; Schizophrenia

PMID:
28277310
DOI:
10.1016/j.schres.2016.10.030
[Indexed for MEDLINE]

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